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Vice President: Mahamudu Bawumia (since 2017)
Cabinet: The Cabinet is made up of the President, the Vice President, and all Ministers of State. It is the principal policy-making organ of the government.
Minister of Finance: Ken Ofori-Atta (since 2017)
Minister of Foreign Affairs: Shirley Ayorkor Botchwey (since 2017)
Minister of Defence: Dominic Nitiwul (since 2017)
Minister of the Interior: Ambrose Dery (since 2017)
Minister of Justice and Attorney-General: Gloria Akuffo (since 2017)
Minister of Education: Dr. Matthew Opoku Prempeh (since 2017)
Minister of Health: Kwaku Agyemang-Manu (since 2017)
Minister of Agriculture: Dr. Owusu Afriyie Akoto (since 2017)
Minister of Trade and Industry: Alan Kyerematen (since 2017)
Minister of Communications: Ursula Owusu-Ekuful (since 2017)
Minister of Energy: John Peter Amewu (since 2017)
Minister of Environment, Science, Technology and Innovation: Professor Kwabena Frimpong-Boateng (since 2017)
Minister of Local Government and Rural Development: Hajia Alima Mahama (since 2017)
Minister of Gender, Children and Social Protection: Cynthia Morrison (since 2017)
Minister of Tourism, Arts and Culture: Catherine Afeku (since 2017)
Minister of Roads and Highways: Kwasi Amoako-Attah (since 2017)
Minister of Water Resources and Sanitation: Cecilia Abena Dapaah (since 2017)
Minister of Aviation: Joseph Kofi Adda (since 2017)
Minister of Railway Development: Joe Ghartey (since 2017)
Minister of Inner-City and Zongo Development: Dr. Mustapha Abdul-Hamid (since 2017)
Minister of Regional Reorganization and Development: Dan Botwe (since 2017)
Minister of Monitoring and Evaluation: Dr. Anthony Akoto Osei (since 2017)
Minister of Special Development Initiatives: Hawa Koomson (since 2017)
Minister of Public Sector Reform: Ignatius Baffour Awuah (since 2017)
Minister of Information: Kojo Oppong Nkrumah (since 2018)