Ghana operates a presidential system. The President is both head of state and government, elected for four-year terms (two-term limit). The Cabinet, chaired by the President, is the principal policy organ.
| Ministry | Minister (since 2017 unless noted) |
|---|---|
| Finance | Ken Ofori-Atta |
| Foreign Affairs & Regional Integration | Shirley Ayorkor Botchwey |
| Defence | Dominic Nitiwul |
| Interior | Ambrose Dery |
| Justice & Attorney-General | Godfred Yeboah Dame (2021) |
| Education | Dr. Yaw Osei Adutwum (2021) |
| Health | Kwaku Agyeman-Manu |
| Food & Agriculture | Bryan Acheampong (2023) |
| Trade & Industry | K.T. Hammond (2023) |
| Energy | Matthew Opoku Prempeh (2021) |
| Roads & Highways | Kwasi Amoako-Atta |
| Railways Development | John-Peter Amewu (2021) |
| Communications & Digitalisation | Ursula Owusu-Ekuful |
| Lands & Natural Resources | Samuel Abu Jinapor (2021) |
| Sanitation & Water Resources | Cecilia Abena Dapaah (2021) |
| Local Gov't, Decentralisation & Rural Development | Daniel Botwe (2021) |
| Gender, Children & Social Protection | Lariba Zuweira Abudu (2023) |
| Tourism, Arts & Culture | Ibrahim Mohammed Awal (2021) |
| Employment & Labour Relations | Ignatius Baffour Awuah |
| Information | Fatima Abubakar (2023) |
| National Security | Albert Kan-Dapaah |
| Parliamentary Affairs | Osei Kyei-Mensah-Bonsu (Majority Leader) |