Calgary, Alberta and Niagara Falls, Ontario are separated by approximately 3,450 kilometers (2,145 miles) by road—a significant cross-country journey spanning three provinces.
The most direct driving route follows the Trans-Canada Highway (Highway 1) east through Alberta, Saskatchewan, and Manitoba, then transitions to Ontario's Highway 17/417 through Thunder Bay, Sault Ste. Marie, Sudbury, and North Bay before reaching Southern Ontario's 400-series highways to Niagara.
The U.S. side (Niagara Falls, NY) is marginally closer to Calgary at ~3,380 km (2,100 miles), but requires border crossing logistics. Most Canadian travelers visit the Ontario side for the superior Horseshoe Falls views and Canadian amenities.