First, a quick correction: the city in the Rio Grande Valley is spelled Edinburg (not "Edingburg"). It’s the Hidalgo County seat and home to the University of Texas Rio Grande Valley.
The drive transitions from subtropical Valley flats (citrus groves, palm trees) through the brush country of South Texas (mesquite, live oak, ranch land) into the rolling Hills near San Antonio. Fuel up in Edinburg or Alice—services thin out on the 80-mile stretch through the ranchlands. Border Patrol checkpoints are permanent fixtures on US-281/I-69C north of Falfurrias; have ID ready (US citizens: driver’s license suffices).
Bottom line: It’s an easy, mostly interstate-grade haul. Leave early to beat San Antonio rush hour, and keep water in the car—South Texas heat is no joke.