* Jacques Marquette and Louis Jolliet (1673): Explored the Mississippi River and reached the mouth of the Arkansas River.
* Robert Cavelier, Sieur de La Salle (1682): Explored the Mississippi River to its mouth and claimed the entire Mississippi Valley for France.
* Pierre Le Moyne, Sieur d'Iberville (1699): Founded the French colony of Louisiana.
* Jean Baptiste Le Moyne, Sieur de Bienville (1702): Founded the city of New Orleans.
Spanish
* Juan de Oñate (1598): Led the first Spanish expedition into the Rocky Mountain region.
* Eusebio Francisco Kino (1691): Explored the Sonoran Desert and founded several missions in Arizona.
* Juan Bautista de Anza (1775): Led an expedition from Mexico to California, establishing the first overland route between the two regions.
American
* John Colter (1807): Was a member of the Lewis and Clark Expedition and became the first American to visit Yellowstone National Park.
* Jedediah Smith (1823): Explored the Rocky Mountains and the Great Basin, becoming the first American to cross the Sierra Nevada Mountains.
* Jim Bridger (1824): Explored the Rocky Mountains and the Yellowstone region, becoming a著名的 mountain man and guide.
* Kit Carson (1826): Explored the Rocky Mountains and the Southwest, becoming a berühmten mountain man and guide.
British
* David Thompson (1793): Explored the Rocky Mountains and the Columbia River region, becoming the first European to cross the Rocky Mountains at Athabasca Pass.
* Simon Fraser (1808): Explored the Fraser River in British Columbia, becoming the first European to travel its entire length.
* John Palliser (1857): Led an expedition to explore the Canadian prairies and the Rocky Mountains, resulting in the publication of the Palliser Reports.