Is Istanbul the only city located in two continents?

Istanbul is indeed a transcontinental city, situated in both Europe and Asia. However, it is not the only city in the world that holds this distinction. Here are some other prominent cities that are located in two continents:

1. Copenhagen, Denmark: Copenhagen, the capital of Denmark, is separated by the Øresund strait, with a small part of the city situated in Sweden. This Swedish part is known as "Amager".

2. Moscow, Russia: Moscow straddles the Moscow River and is considered to be both European and Asian. The Ural Mountains, which are the traditional dividing line between Europe and Asia, run through the city's eastern outskirts.

3. Suez, Egypt: Suez, a port city in Egypt, lies on the Suez Canal, which connects the Mediterranean Sea to the Red Sea. It is located on the African continent but also has a small part in Asia.

4. Panama City, Panama: Panama City is the capital of Panama and lies on the Isthmus of Panama. It borders the Panama Canal, which separates North America and South America, making Panama City a transcontinental city.

These cities share the unique characteristic of being located in two continents, each offering distinct cultural, geographic, and historical features within its boundaries.