No. The Colorado River's headwaters are in the Rocky Mountains of north-central Colorado (Grand County, near Grand Lake). It flows southwest through Colorado, then Utah, Arizona (including Grand Canyon), Nevada (Lake Mead), California, and into Mexico's Gulf of California. Wyoming lies north of Colorado; its major rivers (Green, Bear, North Platte) belong to the Mississippi/Columbia/Great Basin systems. The Green River (Colorado's largest tributary) rises in Wyoming but joins the Colorado in Utah.