Shortest driving route St. Louis to Tampa Bay?

- Distance: 1,127 miles

- Time: Approximately 18 hours 22 minutes

- Route:

1. Take I-55 S from St. Louis, MO towards Memphis, TN

2. In Memphis, merge onto I-40 E towards Nashville, TN

3. Continue on I-40 E to Knoxville, TN.

4. In Knoxville, take I-75 S towards Chattanooga, TN

5. Remain on I-75 S through Georgia all the way to Tampa, FL

***

Option 2 via I-24 East:

- Distance: 1,254 miles

- Time: Approximately 19 hours 23 minutes

- Route:

1. Take I-64 E from St. Louis, MO towards Louisville, KY

2. Continue on I-64 E towards Lexington, KY.

3. In Lexington, merge onto I-75 S towards Knoxville, TN.

4. Take I-24 E in Chattanooga, TN towards Georgia

5. Stay on I-24 E the entire way all the way to Jacksonville, FL.

6. Take I-95 S from Jacksonville, FL to the Tampa Bay Area.