Driving from Charleston, SC to Anna Maria Island, FL: ~650 Miles

The drive is approximately 650 miles via:

1. I-26 W → I-95 S (through Savannah, Jacksonville)
2. FL-A1A S (coastal route via St. Augustine, Daytona, Melbourne)
3. I-4 W (Orlando, Tampa)
4. FL-64 W across Cortez Bridge to Anna Maria Island

Allow 10+ hours; consider traffic, stops, tolls.