- The Catedral Primada de América: This cathedral is the oldest cathedral in the Americas, dating back to the 16th century. It is a beautiful example of Spanish colonial architecture and is home to many important works of art, including paintings by Bartolomé Esteban Murillo and Pedro de Mena.
- The Alcázar de Colón: This palace was built in the 16th century by Diego Columbus, the son of Christopher Columbus. It is a beautiful example of Spanish Renaissance architecture and is now a museum that houses a collection of artifacts from the colonial period.