The wealthiest families in Panama include: 1. The Motta Family (~$2.5B) – supermarket chain Supermercados Rey, retail, real estate, financial services. 2. The Arias Family (~$2B) – banking (Banco General), real estate, power generation. 3. The Eleta Family (~$1.8B) – media, real estate, tourism, transportation. 4. The Fábrega Family (~$1.5B) – banking, telecommunications, real estate. 5. The Vallarino Family (~$1B) – luxury real estate development. Net worth estimates are approximate and subject to market fluctuations.