The encounter was defined by asymmetric power, violence, and systemic exploitation:
Conquistadors (Cortés, Pizarro, etc.) used superior arms, horses, disease, and native alliances to topple empires (Aztec, Inca). The encomienda system granted settlers "protection" of indigenous communities in exchange for forced labor/tribute—de facto slavery.
Eurasian diseases (smallpox, measles, influenza) killed 80–95% of native populations within a century. Labor shortages drove African slave trade.
Missions forcibly converted millions. Temples destroyed; codices burned. Yet syncretic Catholicism emerged (Virgin of Guadalupe, Andean festivals blending Pachamama/Virgin). Indigenous languages (Quechua, Nahuatl, Maya) survive.
Deep structural inequality persists. Modern movements demand land rights, cultural recognition, prior consultation, and plurinational states (Bolivia, Ecuador).