Distance from Gatlinburg, TN to New Orleans, LA

The driving distance between Gatlinburg, Tennessee and New Orleans, Louisiana is approximately 591 miles (951 km) via I-40 W → I-55 S / I-59 S.

• Drive time: ~9–10 hours (without stops).
• Major waypoints: Knoxville → Memphis (cross Mississippi River) → Hattiesburg → New Orleans.
• Alternative: Fly McGhee Tyson (TYS) → Louis Armstrong (MSY) ~1h 45m nonstop.

Gatlinburg (Smokies) to NOLA (French Quarter) = mountains to delta, distinct vibes, one long road trip.