- Capital of Amazonas state and largest city in the Brazilian Amazon
- Major port city and economic hub
- Meeting point of the Negro and Solimões rivers
2. Iquitos, Peru
- Located in the Peruvian Amazon
- Major port and commercial center
- Base for ecotourism and jungle exploration
3. Belém, Brazil
- Capital of Pará state and gateway to the Amazon River
- Historic center with colonial architecture and museums
- Important port and industrial city
