Major Cities Along the Indus River

The Indus River does not flow through any major cities along its main stem.

It originates in Tibet, traverses the Indian union territory of Ladakh (passing near Leh), enters Pakistan through Gilgit-Baltistan (near Gilgit and Nanga Parbat), crosses the Punjab and Sindh plains, and empties into the Arabian Sea. Major urban centers like Lahore, Multan, and Karachi lie on tributaries or near the delta, not on the main channel.