Geographic differences
* The Great Lakes states are located in the northern part of the United States, while the Heartland is located in the central part of the country.
* The Great Lakes states are bordered by Canada, while the Heartland is bordered by Canada and Mexico.
* The Great Lakes states have a significant amount of coastline, while the Heartland has very little.
Economic differences
* The Great Lakes states have a diverse economy, with a mix of manufacturing, agriculture, and service industries.
* The Heartland is primarily an agricultural region, with some manufacturing and service industries.
* The Great Lakes states have a higher GDP per capita than the Heartland.
Cultural differences
* The Great Lakes states are known for their liberal politics, while the Heartland is known for its conservative politics.
* The Great Lakes states have a more diverse population, while the Heartland is more homogeneous.
* The Great Lakes states have a stronger arts and culture scene, while the Heartland is more focused on sports and outdoor activities.