Texas was vast (≈France-sized) with a long Mexican border. Annexation would dramatically expand U.S. power on the continent.
Mexico abolished slavery (1829). Texas, settled by Southern U.S. migrants, reinstated it. Mexico feared a slave empire on its border.
By 1830s, Anglo-Americans outnumbered Tejanos. Mexico suspected they'd revolt and seek U.S. annexation—as they did (1836 Texas Revolution).
Mexico never recognized Texas independence, considering it a rebellious province. Annexation (1845) triggered the Mexican–American War (1846–48), costing Mexico half its territory.