What two groups of people are most Mexicans desended from?

Mexicans are mostly descended from two groups of people: Indigenous Mexicans and Spaniards.

Indigenous Mexicans are the descendants of the people who lived in what is now Mexico before the arrival of the Spanish in the 16th century. These peoples included the Aztecs, Mayas, Zapotecs, Mixtecs, and Otomi.

Spaniards are the descendants of the people who came to Mexico from Spain beginning in the 16th century. These people were mostly explorers, soldiers, and settlers.