Is San Francisco a Spanish name?

Yes, San Francisco is a Spanish name. It is the Spanish language version of Saint Francis. The city of San Francisco in California, United States, is named after Saint Francis of Assisi, the patron saint of the city. The Spanish explorer Juan Rodríguez Cabrillo named the area when he encountered it in 1542 and the original Spanish mission and settlement were founded under the full name "Misión San Francisco de Asís." Over time, the name was shortened to San Francisco.