Yes, "California" is of Spanish origin.
The name first appears in Las Sergas de Esplandián (The Adventures of Esplandián), a 1510 chivalry romance by Garci Rodríguez de Montalvo. It describes a mythical island:
"Know that on the right hand of the Indies there is an island called California, very close to the side of the Terrestrial Paradise, and it was peopled by black women, without any man among them, for they lived in the manner of Amazons... Their arms were all of gold... and there was no metal in the whole island but gold."
The island was ruled by Queen Calafia (likely from Arabic khalifa – caliph/successor).
Thus, California is one of the few US state names derived from a fictional literary queen, filtered through Spanish exploration.