The Rio Grande was central to the Mexican-American War (1846–1848):
The U.S. claimed the border was the Nueces River; Mexico claimed the Rio Grande. The disputed "Nueces Strip" fueled tensions.
General Zachary Taylor established a stronghold on the Rio Grande's southern banks in early 1846, controlling crossings and monitoring Mexican movements.
The first armed conflict occurred April 25, 1846, when Mexican cavalry crossed the river and attacked a U.S. supply column, sparking the Battle of Palo Alto.
The river served as a crucial transportation route and staging area. The Battle of Resaca de la Palma secured U.S. control of the disputed territory.
The 1848 Treaty of Guadalupe Hidalgo established the Rio Grande as the official border from its mouth to El Paso.