You cannot go there—it doesn't exist.
Quahog, Rhode Island is the fictional hometown of the Griffin family in Seth MacFarlane's animated series Family Guy. The show's establishing shots borrow from Providence and Cranston, but no "Spooner Street" exists in any Rhode Island municipality.
Visit Federal Hill (Little Italy), Wickenden Street (Fox Point), or Narragansett Brewery — real Providence neighborhoods with the same gritty charm the show caricatures.
For the Griffins' house, you'll need a TV remote, not a GPS.