At the moment of sustained European arrival (late 15th/early 16th century), two overarching generalizations hold:
The continent hosted hundreds of distinct societies speaking 300+ languages across 50+ language families. They spanned every subsistence strategy: complex agrarian civilizations (Mississippian, Ancestral Pueblo, Mesoamerican-influenced), horticultural villagers, nomadic bison hunters, maritime foragers, and specialized fisher-gatherers. Political forms ranged from egalitarian bands to confederacies (Haudenosaunee, Powhatan) to theocratic city-states. This was not a "wilderness"—it was a humanized landscape shaped by millennia of stewardship.
Within 150–300 years, Indigenous populations declined by 80–95% in most regions due to:
Societies that had thrived for millennia were shattered. Survivors reconstituted, but the pre-contact world was irreversibly lost. This duality—rich diversity → devastating rupture—frames all subsequent North American history.