Appalachian Region Population: 25.3 Million (2020 Census)

The 2020 U.S. Census recorded 25,354,863 residents in the Appalachian Region, making it the nation's 8th most populous region—behind the Great Lakes, Mid-Atlantic, Northeast, Pacific, Rocky Mountains, South, and West South Central. The region spans 13 states from New York to Mississippi, encompassing diverse urban, suburban, and rural communities.