What is the most direct route from Buffalo NY to Lexington KY?

The best route from Buffalo, New York to Lexington, Kentucky is:

1. Head southwest on I-190 S toward US 219 S.

2. Take exit 1A on the left onto I-90 E.

3. Take exit 56 for US-219 S/NY-242 S.

4. Continue straight onto I-390 S.

5. Take I-490 E to NY-15.

6. Take NY-15 S to I-86 W.

7. Take I-86 W to PA-14.

8. Continue straight onto US-15 S.

9. Continue to follow US-15 S to Lexington, Kentucky.

This route will take 9 hours 45 minutes via driving and will take you through the city of Erie.