Driving from Buffalo, NY to Lexington, KY: Most Direct Route

1. Take I-190 S to I-90 E.
2. Exit 56 for US-219 S/NY-242 S.
3. Continue onto I-390 S.
4. Take I-490 E to NY-15.
5. Take NY-15 S to I-86 W.
6. Take I-86 W to PA-14.
7. Continue onto US-15 S.
8. Follow US-15 S to Lexington, KY.

Total: ~9 hr 45 min, passing through Erie, PA. This route minimizes backtracking and uses major highways.