What separates America and South why?

America (or the United States of America) is separated from South America by the Isthmus of Panama, located in Central America. The Isthmus of Panama is a narrow stretch of land that connects North America to South America. The Panama Canal, a man-made waterway, cuts through the Isthmus of Panama and connects the Atlantic Ocean to the Pacific Ocean, providing a vital shipping route between the two oceans.