- John C. Calhoun: Calhoun was a prominent statesman from South Carolina who served as vice president under two presidents, John Quincy Adams and Andrew Jackson. He was a strong advocate for states' rights and a proponent of the Doctrine of Nullification, which argued that states could nullify federal laws that they deemed unconstitutional.
- Mary Chestnut: Chestnut was a wealthy planter and diarist from South Carolina. Her diary of life on her plantation, "A Diary from Dixie," provides a valuable glimpse into the experiences of Southern women during the Civil War.
- Robert Smalls: Smalls was an enslaved African American who became a hero during the Civil War. In 1862, he led a group of enslaved people in capturing a Confederate ship and sailing it to the Union fleet, earning him the rank of captain and making him one of the first African American naval officers in the United States.
- Strom Thurmond: Thurmond was a prominent political figure from South Carolina who served as a U.S. Senator for nearly half a century. He was known for his conservative political views and was a staunch supporter of segregation.
- Nikki Haley: Haley is a politician and diplomat from South Carolina who served as governor of the state before becoming the United States Ambassador to the United Nations under President Donald Trump. She is known for her strong political views and her advocacy for conservative policies.
- James Brown: Brown, known as the "Godfather of Soul," was an iconic musician from South Carolina. His influence on popular music is immeasurable, and his music continues to inspire and influence musicians worldwide.
- Charles Pinckney: Pinckney was a distinguished statesman from South Carolina who played a vital role in shaping the early republic. He was a respected orator and delegate at the Constitutional Convention and served as the 24th U.S. vice president.