# Travel >> Destinations >> South America

Driving Times from Houston to Major South Carolina Cities

South Carolina is 1,000–1,100 miles from Houston. Drive times assume normal traffic, no extended stops, and Interstate routing (primarily I-10 E → I-20 E / I-12 E → I-59 N → I-20 E → I-26 E / I-95 S).

Destination	Distance	Drive Time	Primary Route
Charleston	~1,050 mi	15–16 hrs	I-10 E → I-59 N → I-20 E → I-26 E
Columbia	~1,000 mi	14–15 hrs	I-10 E → I-20 E → I-26 E
Greenville / Spartanburg	~1,080 mi	15–16 hrs	I-10 E → I-20 E → I-85 S
Myrtle Beach	~1,070 mi	15–16 hrs	I-10 E → I-20 E → I-95 S → US-501

Real-World Advice

Break into two days (overnight in Baton Rouge, Mobile, or Birmingham).
Traffic around Atlanta (I-285/I-75/I-85) can add 1–3 hours; consider I-22 via Tupelo to bypass.
Fuel stops: plan every 300–350 miles.

Flying (IAH/HOU → CHS/CAE/GSP/MYR) takes 2.5–3 hours + airport time—often cheaper when booked early.

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South America