Is Africa East of South America?

No. Africa lies northeast of South America.

From South America's eastern bulge (Brazil), the shortest great-circle path to Africa (Gulf of Guinea) heads ENE (~060°). The South Atlantic separates them—narrowest point: ~2,575 km (1,600 mi) between Natal, Brazil and Monrovia, Liberia.

Map projections (especially Mercator) can distort this relationship. On a globe, the azimuth is clearly northeast.

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