West Palm Beach to Key West by Bus: Greyhound Route Details

Yes, you can take a direct bus from West Palm Beach to Key West. Greyhound operates this route daily.

Route Summary

• Carrier: Greyhound Lines
• Frequency: 1–2 daily departures (varies by season/day)
• Duration: ~5 hours 45 minutes (scheduled)
• Fare: ~$45–$75 one-way (advance purchase cheaper; walk-up higher)
• Stops: Typically West Palm Beach → Fort Lauderdale → Miami → Marathon → Key West (may vary)

Departure / Arrival Points

• West Palm Beach: Greyhound Station, 300 S Tamarind Ave, WPB 33401 (downtown, near Tri-Rail/Amtrak).
• Key West: Greyhound Stop, 3420 Duck Ave, Key West 33040 (near Key West Intl Airport / Roosevelt Blvd).

Booking Tips

• Book online early (Greyhound.com/app) for lowest fares & guaranteed seat.
• Arrive 45–60 min early—WPB station is small, lines form.
• Baggage: 1 carry-on + 1 checked bag (50 lbs) included. Extra bags $15+.
• ID required for ticket pickup.
• No Wi-Fi guarantee on all buses; download entertainment.
• Food stops: Usually 1–2 rest stops (Miami, Marathon). Pack snacks/water.

Alternatives

• Drive: ~3h 45m (165 mi via US-1 / Overseas Highway). Scenic, flexible, ~$30 gas. Best option if you can drive.
• Keys Shuttle / Florida Keys Express: Door-to-door van services (shared/private). ~$85–120 pp. More convenient, faster.
• Fly: WPB (PBI) → Key West (EYW) ~1h flight (Silver Airways, seasonal). $150–300+.
• Brightline + Shuttle: Brightline train WPB → MiamiCentral (1h15m), then Keys Shuttle/rental car to Key West (~3h).

Bottom Line

Greyhound works if you can't drive, want cheapest public transit, and have time. For most, driving the Overseas Highway is the experience—Seven Mile Bridge, Bahia Honda, Key Lime pie stops, sunset at Mallory Square. The bus just gets you there.