The driving distance from Charlottesville, Virginia to West Palm Beach, Florida is about 1,050 miles (1,690 km) via I-64 → I-81 → I-77 → I-26 → I-95 (or similar).
Typical drive time: 15.5–17 hours without extended stops. Traffic around Richmond, Columbia, Savannah, Jacksonville, and South Florida can add hours. Consider a two-day trip with overnight in Savannah or Jacksonville.