Is there a bus from Annapolis Maryland to Philadelphia?

Yes, there are several buses that run from Annapolis, Maryland to Philadelphia, Pennsylvania. The most direct route is the Greyhound bus, which takes about 3 hours and 45 minutes. There are also several other bus companies that offer service between these two cities, including Megabus, BoltBus, and FlixBus. The trip can take anywhere from 3 to 5 hours, depending on the time of day and the route taken.