Driving Time from Knoxville, TN to Mobile, AL

The drive from Knoxville, Tennessee to Mobile, Alabama covers approximately 372 miles (599 km) and takes 6 hours 10 minutes – 6 hours 30 minutes under normal conditions.

Primary Route

1. I-75 South (Knoxville → Chattanooga) – ~112 mi
2. I-24 West (Chattanooga → near Monteagle) – ~45 mi
3. I-59 South (Monteagle → Birmingham → Meridian) – ~160 mi
4. I-20 East / I-59 South (Birmingham split)
5. US-45 South / AL-217 (Meridian → Mobile) – ~55 mi

Alternate Route

I-40 West → I-22 East → I-65 South (via Memphis, Tupelo, Birmingham) – similar distance, slightly longer time.

Tips

• Traffic around Chattanooga and Birmingham can add 30–60 min at rush hour.
• Rest stops: Monteagle (TN), Cullman (AL), Meridian (MS).
• Scenic option: Natchez Trace Parkway (adds time, beautiful).