How long does it take to drive from Newport Oregon Portland Maine?

There is no direct route from Newport, Oregon to Portland, Maine by car. The shortest route would be to take Interstate 84 east from Portland, Oregon to Ontario, Oregon, then take Interstate 90 east to Boston, Massachusetts and then Route 1 south to Portland, Maine. This route is approximately 3,300 miles and would take at least 46 hours of driving time without stops.