The drive from the Las Vegas Strip to the Bright Angel Lodge at the Grand Canyon's South Rim is approximately 275 miles (440 km) and takes about 4 hours and 30 minutes under normal traffic conditions via US-93 N and I-40 E / AZ-64 N.
Allow extra time for traffic, construction, weather (especially winter), and stops at viewpoints like Hoover Dam or Route 66 attractions in Seligman.