A flight from the Amazon River basin (South America) to Los Angeles (western USA) follows a generally northwesterly trajectory. You’d cross the northern tier of South America, traverse Central America, and then continue over the eastern Pacific Ocean to reach the California coast.
The exact heading varies with the departure point on the Amazon and the flight plan, but the overall direction is northwest, covering roughly 5,000–6,000 km (3,100–3,700 mi).