How long does it take to get from Syracuse NY Charlotte NY?

There are a few different routes you can take from Syracuse, NY to Charlotte, NY, and the drive time will depend on the route you choose. The fastest route is to take Interstate 81 South, which will take you about 5 hours and 30 minutes without traffic delays. Other options include taking Route 20 West or Route 155 South, but these routes will take you about an hour longer.