What Were two difficulties settlers faced on the Oregon trail?

1. Disease: Cholera, dysentery, and other diseases often spread quickly among the pioneers due to poor sanitation and hygiene. The crowded and unsanitary conditions on the trail made the spread of diseases even more rapid.

2. Weather: From oppressive summer heat and blinding dust storms in the deserts to bitterly cold winters in the mountains and blizzards on the plains, settlers had to endure a wide range of harsh and unpredictable weather conditions. Extreme weather conditions posed serious threats to the health and well-being of the settlers.