Contrary to a common misconception, General Antonio López de Santa Anna did not lead his army across the Rio Grande during the Texas Revolution. The Mexican Army's 1836 campaign into Texas actually crossed the Nueces River, which at the time marked the disputed northeastern boundary of Mexican Texas. The Rio Grande lay farther south and was not the invasion route.
This distinction matters historically because the territory between the Nueces and the Rio Grande was contested—Mexico recognized the Nueces as the border, while the Republic of Texas claimed the Rio Grande. Santa Anna's forces marched from the Mexican interior, crossed the Nueces, and advanced toward San Antonio de Béxar, culminating in the Battle of the Alamo and the Goliad Campaign. The Rio Grande became the de facto border only after the Mexican–American War (1846–1848) and the Treaty of Guadalupe Hidalgo.