1) Take I-35 S in Minneapolis
2) Take Interstate 35 S to Interstate 29 S in Missouri
3) Take Interstate 29 S to Interstate 44 W in Oklahoma
4) Take Interstate 44 W to Interstate 40 W in Oklahoma
5) Take Interstate 40 W to U.S. Route 66 W (National Trails Highway) in Arizona
6) Take U.S. Route 66 W to Las Vegas
This route is approximately 1,900 miles and takes around 28 hours to drive without stopping. Please note that the best route may vary depending on the time of day and year.