Wanderlust World Wanderlust World The drive from Buffalo, New York to Myrtle Beach, South Carolina covers approximately 840 miles and takes about 13 hours and 55 minutes under normal traffic conditions.
The most direct route typically follows I-90 east to I-86, then connects to I-81 south through Pennsylvania, crossing into Maryland briefly before entering Virginia. From there, drivers take I-77 south through West Virginia and Virginia into North Carolina, finally connecting to US-74 east or I-95 south to reach Myrtle Beach.
Plan for rest stops and fuel breaks, especially in mountainous areas of West Virginia and Virginia. Traffic can be heavy around major metros like Harrisburg, Roanoke, and Charlotte. Consider splitting the trip into two days for a more relaxed journey.