Driving Distance: New Orleans to St. Louis ~670 Miles

The most direct route (I-55 N → I-64 W / I-70 W) from New Orleans, LA to St. Louis, MO is approximately 670 miles (1,078 km). Typical drive time: 10–11 hours without long stops. Traffic around Memphis, Little Rock, or St. Louis metro can add 1–2 hours. Alternate via I-40/I-44 is similar distance.