Driving from St. Louis to Florida: 13–20 Hours Depending on Destination
Major Florida Destinations from St. Louis
| Destination | Distance | Drive Time (no stops) |
|---|
| Jacksonville | ~850 mi | ~13 hrs |
| Orlando | ~1,050 mi | ~16 hrs |
| Tampa | ~1,100 mi | ~17 hrs |
| Miami | ~1,250 mi | ~19–20 hrs |
| Key West | ~1,450 mi | ~22+ hrs |
Routes
- I-55 S → I-24 E → I-75 S (via Nashville, Atlanta) — most common to peninsula.
- I-55 S → I-10 E (via Memphis, Birmingham, Mobile) — to Panhandle.
Real-World Advice
- Add 2–4 hours for fuel, food, rest.
- Two-day drive recommended (overnight in Atlanta, Birmingham, or Tallahassee).
- Check traffic (Atlanta bottleneck), weather, construction.
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