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- Interstate 10: Connects major cities in the southern United States, from Los Angeles to Jacksonville.
- Interstate 20: Runs east-west across the southern United States, from Charleston, South Carolina, to Phoenix, Arizona.
- Interstate 40: Connects the Great Lakes region with California, passing through major cities such as Chicago, St. Louis, Albuquerque, and Los Angeles.
- Interstate 5: Runs along the Pacific Coast, from Washington state to California.
- Interstate 80: Connects major cities in the northern United States, from San Francisco to New York City.
- Interstate 95: Runs along the Atlantic Coast, from Maine to Florida.
Major highways in Europe:
- Autobahn (Germany): A network of freeways that connect major German cities.
- Autoroutes (France): A network of motorways that connect major French cities.
- Autostrade (Italy): A network of highways that connect major Italian cities.
- Motorways (United Kingdom): A network of highways that connect major British cities.
- Autopistas (Spain): A network of highways that connect major Spanish cities.
Major highways in Asia:
- China National Highways: A network of highways that connect major Chinese cities.
- Indian National Highways: A network of highways that connect major Indian cities.
- Japan National Highways: A network of highways that connect major Japanese cities.
- Korean National Highways: A network of highways that connect major South Korean cities.
- Thai National Highways: A network of highways that connect major Thai cities.