Boston to Philadelphia:
- Take I-93 South to I-495 South: Travel for about 17 miles on I-495 South.
- Take Exit 14 for MA-24 South: Continue for about 1 mile on MA-24 South.
- Take Exit 19A for US-1 South: Drive approximately 199 miles on US-1 South.
- Continue on I-95 South to Philadelphia: Drive for about 298 miles on I-95 South.
Philadelphia to Charlotte:
- Take I-476 South to US-1 South: Drive for about 20 miles on I-476 South and merge onto US-1 South.
- Continue on US-1 South to Florence: Continue for about 205 miles on US-1 South.
- Take I-20 West to Charlotte: Drive for approximately 165 miles on I-20 West.
Charlotte to Jacksonville:
- Take I-85 South to Greenville: Drive for about 133 miles on I-85 South.
- Take I-385 South to I-26 East: Drive for about 14 miles on I-385 South and merge onto I-26 East.
- Continue on I-26 East to Jacksonville: Drive for about 185 miles on I-26 East.
Jacksonville to Miami:
- Take I-95 South to Miami: Drive for about 350 miles on I-95 South.