Wanderlust World Wanderlust World The drive from Kansas City, MO to Pittsburgh, PA is approximately 900 miles (1,450 km) and takes about 13–14 hours of driving time (not including stops).
Common route: I-70 East across Missouri, Illinois, Indiana, Ohio, then I-76 East (Pennsylvania Turnpike) to Pittsburgh.
Actual time varies with traffic (especially St. Louis, Indianapolis, Columbus, Pittsburgh metro), weather, construction, and rest breaks. Plan for a full day or two-day trip.