How long does it take to drive from Chapel Hill North Carolina San Francisco California?

It is not possible to drive from Chapel Hill, North Carolina to San Francisco, California because there is no direct route. You can drive from Raleigh/Durham International Airport (RDU) to San Francisco International Airport (SFO) in just over 6 hours, but this would require taking a plane. The distance between Chapel Hill and San Francisco is approximately 2,700 miles, and the drive would take approximately 42 hours without stopping. This includes taking interstates 40, 81, 70, 76, and 25, as well as some smaller roads. It would likely take longer if you factor in stops for gas, food, and rest.