The drive from Naples, Florida to Nashville, Tennessee spans approximately 1,100 miles (1,770 km). At a constant 60 mph with zero stops, the pure driving time is 18.3 hours.
No one drives 1,100 miles nonstop at exactly 60 mph. Real-world factors:
One aggressive day: 19–21 hours (not recommended—fatigue risk)
Two comfortable days: ~600 mi Day 1 (Naples → Atlanta/Macon), ~500 mi Day 2 (→ Nashville). Overnight in Macon, GA or Chattanooga, TN.
Three relaxed days: Add a midpoint night in Savannah/Charleston or Atlanta.
I-75 North (Naples → Atlanta) → I-24 West (Atlanta → Chattanooga → Nashville). Alternative: I-10 West → I-65 North (via Mobile/Montgomery/Birmingham) is similar distance/time.
Fuel budget: ~40 gallons @ 27 mpg average = ~$140–160 (2024 prices). Check tire pressure, coolant, and wipers before departing—this is a serious interstate haul.