- In 1532, Spanish conquistadors led by Francisco Pizarro climbed the Andes to reach the Inca capital of Cusco.
- In 1743, French scientist Charles Marie de La Condamine climbed the Andes as part of a geodesic mission to measure the Earth's equator.
- In 1802, German naturalist Alexander von Humboldt climbed the Andes to study the المنطقة الاستوائية ecosystems of the region.
These are just a few examples of the many people who have climbed the Andes over the centuries, and it is likely that even earlier ascents were made by indigenous peoples of the region.