The Nile River is the quintessential example. Its journey spans extreme climatic gradients:
This gradient drives the Nile's paradox: a massive river sustained by rainfall elsewhere, enabling civilization in one of Earth's driest zones. The Blue Nile (monsoonal, July–Sept flood) and White Nile (steady, lake-regulated) create complementary hydrographs that historically produced the predictable annual inundation.
Other examples: Colorado River (Rocky Mountain snowmelt → Sonoran/Mojave Deserts), Amu Darya (Pamir glaciers → Karakum Desert), Orange River (Lesotho highlands → Namib/Kalahari).