The Roanoke River rises in the Blue Ridge Mountains near Roanoke, Virginia, then flows southeast ~660 km (410 mi) through:
Major impoundments (Smith Mountain Lake, Leesville Lake, Kerr, Gaston) regulate flow for hydropower, flood control, and water supply. The lower river's floodplain hosts vast bottomland hardwood forests—critical habitat for migratory birds and anadromous fish (striped bass, shad, herring).
The river's name derives from Algonquian "rawrenock" (shell money/wampum), reflecting its historic importance to Indigenous trade networks.